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Plurol Oleique CC 497

Plurol Oleique CC 497

A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.

  • INCI

    Polyglyceryl-3 Dioleate

  • Generic and alternative names

    Polyglyceryl-3 dioleate NF

  • Claims / benefits / efficacy

    • Oral drug delivery: excipient used in formulations for solubility and bioavailability enhancement.
    • Oral drug delivery: water insoluble surfactant for SELF (self-emulsifying lipidic formulation).
    • Oral/Dermal drug delivery: solubilizer for actives.
    • Dermal drug delivery: W/O surfactant. It improves the stability of emulsions

  • Function

    • Non-ionic water insoluble surfactant;
    • Penetration enhancer;
    • Solubilizer;
    • bioavailability enhancer
    • Co-surfactant

  • Application

    • Oral drug delivery
    • Dermal drug delivery
    • Oral lipid-based formulation SEDDS and SMEDDS
    • Poorly-soluble APIs
    • Topical formulations

  • Packaging

    Steel can 5 kg (BFE)
    Steel drum 25 kg (BFC)

  • Shelf life

    3 years

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